Title
Anti-HIV-1 activity of poly(mandelic acid) derivatives
Document Type
Article
Publication Date
11-1-2007
Abstract
Homo- and heterochiral poly(mandelic acid)s (PMDAs) were synthesized under strongly acidic, mildly acidic, and nonacidic conditions. The water-soluble fractions of these polymers were evaluated with respect to their inhibitory activity against the human immunodeficiency virus (HIV-1). Polymers were prepared via a step-growth mechanism, yielding linear polyesters. The polymers were characterized by CHS elemental microanalysis, X-ray fluorescence (XRF), and FT-IR spectroscopy. Polymers prepared by the three methods have different structures. Both elemental microanalysis and XRF indicated the presence of S in those polymers prepared by treatment with concentrated H2SO4, which were the only ones exhibiting inhibitory and virucidal activity against HIV-1, mediated by their binding to cellular co-receptor binding sites on the virus envelope glycoprotein gp120. Additionally, FT-IR spectroscopy indicated the complete absence of C=O functionality in the H2SO4-prepared PMPDA. © 2007 American Chemical Society.
Publication Source (Journal or Book title)
Biomacromolecules
First Page
3308
Last Page
3316
Recommended Citation
Ward, M., Yu, B., Wyatt, V., Griffith, J., Craft, T., Neurath, A., Strick, N., Li, Y., Wertz, D., Pojman, J., & Lowe, A. (2007). Anti-HIV-1 activity of poly(mandelic acid) derivatives. Biomacromolecules, 8 (11), 3308-3316. https://doi.org/10.1021/bm070221y
