Aerosol Matrix-Assisted Laser Desorption Ionization for Liquid Chromatography/Time-of-Flight Mass Spectrometry
We report the application of aerosol matrix-assisted laser desorption ionization (MALDI) to liquid chromatography/ mass spectrometry (LC/MS). The aerosol MALDI experiment uses aerosol liquid introduction in conjunction with pulsed UV laser ionization to form ions from large biomolecules in solution. Mass analysis is achieved in a time-of-flight mass spectrometer. In the LC/MALDI-MS experiment, the matrix solution is combined with the column effluent in a mixing tee. LC/MALDI-MS is demonstrated for the separation of brady kinin, gramicidin S, and myoglobin. © 1994, American Chemical Society. All rights reserved.
Publication Source (Journal or Book title)
Murray, K., Lewis, T., Beeson, M., & Russell, D. (1994). Aerosol Matrix-Assisted Laser Desorption Ionization for Liquid Chromatography/Time-of-Flight Mass Spectrometry. Analytical Chemistry, 66 (10), 1601-1609. https://doi.org/10.1021/ac00082a003