Document Type

Article

Publication Date

10-1-2004

Abstract

A single droplet generator was coupled with a rotating ball inlet matrix-assisted laser desorption/ionization (MALDI) time of flight (TOF) mass spectrometer. Single droplets with 100 picoliter volume were ejected by a piezoelectric-actuated droplet generator and deposited onto a matrix-coated rotating stainless steel ball at atmospheric pressure. The single droplet deposit was transported to the vacuum side of the instrument where ionization was accomplished using a UV pulsed laser. Using this on-line interface, it was possible to obtain protonated molecule signal from as little as 10 fmol analyte. © 2004 American Society for Mass Spectrometry.

Publication Source (Journal or Book title)

Journal of the American Society for Mass Spectrometry

First Page

1471

Last Page

1477

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