Title

Autism Detection in Children by Combined Use of Gaze Preference and the M-CHAT-R in a Resource-Scarce Setting

Authors

Kelly Jensen, Tulane University School of Medicine, New Orleans, LA, USA.
Sassan Noazin, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. snoazin1@jhu.edu.
Leandra Bitterfeld, Johns Hopkins University School of Nursing, Baltimore, MD, USA.
Andrea Carcelen, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Natalia I. Vargas-Cuentas, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Daniela Hidalgo, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Alejandra Valenzuela, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Avid Roman-Gonzalez, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Casey Krebs, Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Vincent Clement, Psychology Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Cody Nolan, Weill Cornell Medical College, New York, NY, USA.
Franklin Barrientos, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Ardi Knobel Mendoza, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ, USA.
Paola Noriega-Donis, Johns Hopkins University Whiting School of Engineering, Baltimore, MD, USA.
Claudia Palacios, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Andrea Ramirez, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.
Macarena Vittet, Bioinformatics and Molecular Biology Laboratory, Research and Development Laboratory, Science and Philosophy Faculty, Universidad Peruana Cayetano Heredia, Lima, Peru.

Document Type

Article

Publication Date

3-1-2021

Abstract

Most children with autism spectrum disorder (ASD), in resource-limited settings (RLS), are diagnosed after the age of four. Our work confirmed and extended results of Pierce that eye tracking could discriminate between typically developing (TD) children and those with ASD. We demonstrated the initial 15 s was at least as discriminating as the entire video. We evaluated the GP-MCHAT-R, which combines the first 15 s of manually-coded gaze preference (GP) video with M-CHAT-R results on 73 TD children and 28 children with ASD, 36-99 months of age. The GP-MCHAT-R (AUC = 0.89 (95%CI: 0.82-0.95)), performed significantly better than the MCHAT-R (AUC = 0.78 (95%CI: 0.71-0.85)) and gaze preference (AUC = 0.76 (95%CI: 0.64-0.88)) alone. This tool may enable early screening for ASD in RLS.

Publication Source (Journal or Book title)

Journal of autism and developmental disorders

First Page

994

Last Page

1006

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