"pH-Induced reorientation of cytochrome c on silica nanoparticles" by Jens Meissner, Yao Wu et al.

Faculty Publications

Title

pH-Induced reorientation of cytochrome c on silica nanoparticles

Authors

Jens Meissner, Stranski Laboratory of Physical and Theoretical Chemistry, Technical University Berlin, 10623 Berlin, Germany. findenegg@chem.tu-berlin.de.
Yao Wu, Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA. bbharti@lsu.edu.
Jacques Jestin, Laboratoire Léon Brillouin, CEA Saclay 91191 Gif-sur-Yvette Cedex, France.
William A. Shelton, Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA. bbharti@lsu.edu and Center for Computation and Technology, Louisiana State University, Baton Rouge, LA 70803, USA.
Gerhard H. Findenegg, Stranski Laboratory of Physical and Theoretical Chemistry, Technical University Berlin, 10623 Berlin, Germany. findenegg@chem.tu-berlin.de.
Bhuvnesh Bharti, Cain Department of Chemical Engineering, Louisiana State University, Baton Rouge, LA 70803, USA. bbharti@lsu.edu.

Document Type

Article

Publication Date

1-21-2019

Abstract

The orientation of cytochrome c molecules at the surface of silica nanoparticles was studied in a wide pH range by combining small-angle neutron scattering, adsorption measurements, and molecular dynamics simulations. The results indicate a reorientation of the ellipsoidal protein from head-on to side-on as the pH is increased. This is attributed to changes in the surface charge distribution of both the protein and the nanoparticles.

Publication Source (Journal or Book title)

Soft matter

First Page

350

Last Page

354

Recommended Citation

Meissner, J., Wu, Y., Jestin, J., Shelton, W. A., Findenegg, G. H., & Bharti, B. (2019). pH-Induced reorientation of cytochrome c on silica nanoparticles. Soft matter, 15 (3), 350-354. https://doi.org/10.1039/c8sm01909f

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