"Elucidating the Impact of Molecular Structure on the F NMR Dynamics an" by Cheng Zhang, Dong Sub Kim et al.

Faculty Publications

Title

Elucidating the Impact of Molecular Structure on the F NMR Dynamics and MRI Performance of Fluorinated Oligomers

Authors

Cheng Zhang
Dong Sub Kim, Materials Research Laboratory, Materials Department and Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Jimmy Lawrence, Materials Research Laboratory, Materials Department and Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Craig J. Hawker, Materials Research Laboratory, Materials Department and Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, United States.
Andrew K. Whittaker

Document Type

Article

Publication Date

8-21-2018

Abstract

To understand molecular factors that impact the performance of polymeric F magnetic resonance imaging (MRI) agents, a series of discrete fluorinated oligoacrylates with precisely defined structure were prepared through the combination of controlled polymerization and chromatographic separation techniques. These discrete oligomers enabled thorough elucidation of the dependence of F NMR and MRI properties on molecular structure, for example, the chain length. Importantly, the oligomer size and dispersity strongly influence NMR dynamics ( and relaxation times) and MR imaging properties with higher signal-to-noise ratio (SNR) observed for oligomers with longer chain length and shorter . Our approach enables an effective pathway and thus opportunities to rationally design effective polymeric F MR imaging agents with optimized molecular structure and NMR relaxivity.

Publication Source (Journal or Book title)

ACS macro letters

First Page

921

Last Page

926

Recommended Citation

Zhang, C., Kim, D. S., Lawrence, J., Hawker, C. J., & Whittaker, A. K. (2018). Elucidating the Impact of Molecular Structure on the F NMR Dynamics and MRI Performance of Fluorinated Oligomers. ACS macro letters, 7 (8), 921-926. https://doi.org/10.1021/acsmacrolett.8b00433

This document is currently not available here.

COinS