Multi-subunit acetyl-CoA carboxylases

Document Type

Article

Publication Date

7-11-2002

Abstract

Acetyl-CoA carboxylase (ACC) catalyses the first committed step of fatty acid synthesis, the carboxylation of acetyl-CoA to malonyl-CoA. Two physically distinct types of enzymes are found in nature. Bacterial and most plant chloroplasts contain a multi-subunit ACC (MS-ACC) enzyme that is readily dissociated into its component proteins. Mammals, fungi, and plant cytosols contain the second type of ACC, a single large multifunctional polypeptide. This review will focus on the structures, regulation, and enzymatic mechanisms of the bacterial and plant MS-ACCs. Copyright © 2002 Elsevier Science Ltd.

Publication Source (Journal or Book title)

Progress in Lipid Research

First Page

407

Last Page

435

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