Modeling the negative feedback mechanism in the enzyme carboxyltransferase
Document Type
Conference Proceeding
Publication Date
12-1-2011
Abstract
The enzyme acetyl-CoA carboxylase catalyzes the first committed step in fatty acid synthesis in all organisms. The E. coli form of the carboxyltransferase subunit was recently found to regulate its own activity and expression by binding its own mRNA. By binding acetyl-CoA or the mRNA encoding its own subunits, Carboxyltransferase is able to sense the metabolic state of the cell and attenuate its own translation and enzymatic activity using a negative feedback mechanism. In this paper, this network of interactions is modeled mathematically using mass action kinetics. Numerical simulations of the model show agreement with experimental results. Copyright © 2011 by ASME.
Publication Source (Journal or Book title)
ASME 2011 Dynamic Systems and Control Conference and Bath ASME Symposium on Fluid Power and Motion Control Dscc 2011
First Page
531
Last Page
536
Recommended Citation
Cai, X., De Queiroz, M., Meades, G., & Waldrop, G. (2011). Modeling the negative feedback mechanism in the enzyme carboxyltransferase. ASME 2011 Dynamic Systems and Control Conference and Bath ASME Symposium on Fluid Power and Motion Control Dscc 2011, 2, 531-536. https://doi.org/10.1115/DSCC2011-6171