Retrograde Signaling Via Dendritic Activation of Glial-Neuronal Circuits

Document Type

Article

Publication Date

1-1-2021

Abstract

Neuroendocrine cells in the hypothalamus secrete neuropeptides from both their axon terminals and their dendrites to regulate homeostatic function. Vasopressin is expressed in both vasopressin and corticotropin-releasing-hormone neurons and is released dendritically following exposure to homeostatic neuromodulators such as ghrelin and norepinephrine. Dendritically released vasopressin stimulates ATP release from astrocytes, which activates local upstream glutamate and GABA circuits. This trans-neuronal-glial retrograde signaling exploits the spatial domain of astrocytes to expand the reach of dendritic volume transmission from neuroendocrine cells to distal presynaptic partners to regulate local synaptic circuit inputs, thus providing a powerful means of neuroendocrine cell autoregulation of hormonal output.

Publication Source (Journal or Book title)

Masterclass in Neuroendocrinology

First Page

183

Last Page

203

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