Title

Oxidative stress and detoxification mechanisms of earthworms (Eisenia fetida) after exposure to flupyradifurone in a soil-earthworm system

Authors

Zhihua Qiao, State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China; Key Laboratory of Pesticide Toxicology & Application Technique, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, 271018, PR China.
Peiyao Li, College of Agriculture, Qingdao Agricultural University, Qingdao, Shandong, 266109, PR China.
Jiaqi Tan, Department of Biological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA.
Cheng Peng, State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China.
Fengwen Zhang, Key Laboratory of Pesticide Toxicology & Application Technique, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, 271018, PR China; Tobacco Research Institute of Chinese Academy of Agricultural Sciences (CAAS), Qingdao, Shandong, 266101, PR China.
Wei Zhang, State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resource and Environmental Engineering, East China University of Science and Technology, Shanghai, 200237, PR China. Electronic address: wzhang@ecust.edu.cn.
Xingyin Jiang, Key Laboratory of Pesticide Toxicology & Application Technique, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, 271018, PR China. Electronic address: xyjiang@sdau.edu.cn.

Document Type

Article

Publication Date

11-15-2022

Abstract

Flupyradifurone (FLU) has great application potential in agricultural production as a new generation of neonicotinoid insecticide after imidacloprid. Nevertheless, the toxic effects of FLU on non-target soil organisms remain unclear, resulting in considerable environmental risks. We evaluated the acute and subchronic toxicities of FLU to earthworms. The results of acute toxicity show that the median lethal concentration (LC) values (14 d) of FLU were 186.9773 mg kg for adult earthworms and 157.6502 mg kg for juveniles, respectively. The subchronic toxicity of FLU that focused on the activities of antioxidant and detoxication enzymes showed the superoxide dismutase (SOD), catalase (CAT), and glutathione-S transferase (GST) activities in earthworms increased while the peroxidase (POD) and acetylcholinesterase (AChE) activities decreased after exposure to FLU. Oxidative damage analyses revealed that the reactive oxygen species (ROS) level and malonaldehyde (MDA) content in earthworms were increased by FLU, resulting in DNA damage. Transcriptomics and RT-qPCR confirmed that FLU influenced the expression of genes related to antioxidant response and detoxification of earthworms. Ultimately detoxification metabolism, environmental information processing, cell processes, and immune system pathways are significantly enriched to respond jointly to FLU. Our study fills the gaps in the toxicity of FLU to earthworms, providing a basis for its risk assessment of soil ecosystems and non-target biological toxicity.

Publication Source (Journal or Book title)

Journal of environmental management

First Page

115989

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