Title
Growth hormone, but not insulin, activates STAT5 proteins in adipocytes in vitro and in vivo
Document Type
Article
Publication Date
3-7-2003
Abstract
STAT 5 proteins are latent transcription factors which have been shown to be activated by growth hormone (GH) in many cell types. However, some recent studies also suggest that STAT 5B is a physiological substrate of the insulin receptor. In our studies, we have shown that physiological levels of insulin do not induce STAT 5 tyrosine phosphorylation or affect the nuclear distribution of STATs 5A or 5B in 3T3-L1 adipocytes. Moreover, we did not observe the activation of STAT 5 in the adipose tissue or skeletal muscle of mice following an acute intraperitoneal injection of insulin. However, acute GH administration, both in vitro and in vivo, resulted in the activation of STAT 5 proteins. In summary, our results indicate that STAT 5 proteins are not activated by physiological levels of insulin in adipose tissue.
Publication Source (Journal or Book title)
Biochemical and biophysical research communications
First Page
359
Last Page
62
Recommended Citation
Zvonic, S., Story, D. J., Stephens, J. M., & Mynatt, R. L. (2003). Growth hormone, but not insulin, activates STAT5 proteins in adipocytes in vitro and in vivo. Biochemical and biophysical research communications, 302 (2), 359-62. https://doi.org/10.1016/s0006-291x(03)00179-7