"Higher circulating leukocytes in women with PCOS is reversed by aerobi" by Jeffrey D. Covington, Charmaine S. Tam et al.

Faculty Publications

Title

Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise

Authors

Jeffrey D. Covington, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA; Louisiana State University Health Sciences Center, School of Medicine, 433 Bolivar St, New Orleans, LA 70112, USA.
Charmaine S. Tam, The Charles Perkins Centre and The School of Biological Sciences, University of Sydney, 2006 NSW, Australia.
Magdalena Pasarica, Translational Research Institute, Florida Hospital - Stanford-Burnam, 301 E. Princeton Street, Orlando, FL 32804, USA.
Leanne M. Redman, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA. Electronic address: leanne.redman@pbrc.edu.

Document Type

Article

Publication Date

5-1-2016

Abstract

Polycystic ovary syndrome (PCOS) is characterized by insulin resistance, elevated circulating leukocytes, and hypothesized to have higher adipose tissue inflammation. Aerobic exercise reduces circulating leukocytes and improves insulin sensitivity in obese individuals, but the effect of exercise on inflammation in PCOS is not known. We investigated circulating leukocytes, insulin sensitivity by euglycemic-hyperinsulinemic clamp, serum pro- and anti-inflammatory markers (hsCRP, TNF-α, total and high molecular weight adiponectin), and abdominal subcutaneous adipose tissue (SAT) gene expression of proinflammatory markers in 8 PCOS women and 8 obese control females matched for BMI. Additionally, in a prospective study, the 8 women with PCOS underwent a 16-week aerobic exercise regimen with the same measures performed post-intervention. Compared to controls, white blood cell counts (WBC) were 30% higher (p = 0.04) and circulating total adiponectin levels were 150% lower (p = 0.03) in women with PCOS at baseline/pre-exercise conditions. SAT gene expression of macrophage migration inhibitory factor (MIF, p < 0.01) and interleukin-6 (IL-6, p < 0.05) were also lower in women with PCOS. In response to 16 weeks of aerobic exercise, insulin sensitivity improved (p < 0.01) and WBC counts decreased (p = 0.02). The exercise-induced change in WBC and circulating neutrophils correlated inversely with changes in glucose disposal rate (r = -0.73, p = 0.03; and r = -0.82, p = 0.01, respectively). Aerobic exercise reduced serum leptin (p < 0.05) after 4 weeks, trended to reduce the ratio of leptin-to-high molecular weight adiponectin (p < 0.1) by the 8th week, and significantly increased serum dehydroepiandrosterone sulfate (DHEA-S, p < 0.001) after 16 weeks. In conclusion, women with PCOS have higher circulating leukocytes compared to controls, which can be reversed by aerobic exercise and is associated with improvements in insulin sensitivity.

Publication Source (Journal or Book title)

Biochimie

First Page

Last Page

Recommended Citation

Covington, J. D., Tam, C. S., Pasarica, M., & Redman, L. M. (2016). Higher circulating leukocytes in women with PCOS is reversed by aerobic exercise. Biochimie, 124, 27-33. https://doi.org/10.1016/j.biochi.2014.10.028

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