New Pt(II) complexes with n-donor ligands: Potential use as chemotherapeutic agents
Abstract
New complexes of the types, trans-Pt(DMSO)(L)Cl2 and trans- Pt(L)2Cl2 (L = 4-piperidinopyridine (4-(CH2)5Npy), pyppzSO2CH3, and pyppzSO2(3,5-Me2C6H3), were prepared by treating cis- [Pt(DMSO)2Cl2] with L in 1:1 or 1:2 (M:L) molar ratios, respectively. 1H NMR spectroscopic and single-crystal X-ray crystallographic analysis established that the pyridyl ring N is bound to the Pt(II) metal center in all complexes. The molecular structures of all complexes indicate that the Pt(II) ion has a square planar geometry with two trans chloro ligands. The other two positions are occupied by an Sbonded dimethyl sulfoxide and L ligands in the trans- PtII(DMSO)(L)Cl2 complexes and by two L ligands in trans-PtII(L)2Cl2 complexes. These new complexes have structural features similar to that of complexes with known chemotherapeutic properties and thus should be evaluated for anticancer potential.