Concerning the structure of 7α,15β-dichloro-5α-cholest-8(14)-en-3β-ol, a novel inhibitor of cholesterol biosynthesis

Marcia E. Newcomer, Rice University
G. L. Gilliland, Rice University
Edward J. Parish, Rice University
George J. Schroepper, Rice University
Florante A. Quiocho, Rice University

Abstract

Treatment of 3β-p-bromobenzoyloxy-14α, 15α-epoxy-5α-cholest-7-ene with gaseous HCI in chloroform at -25°C gave 3β-p-bromobenzoyloxy-7α, 15β-dichloro-5α-cholest-8(14)-ene in 93% yield. The structure of the latter compound was unequivocally established by the results of X-ray crystallographic analysis. © 1980.