Document Type
Article
Publication Date
1-14-2011
Abstract
The synthesis of both proinflammatory leukotrienes and anti-inflammatory lipoxins requires the enzyme 5-lipoxygenase (5-LOX). 5-LOX activity is short-lived, apparently in part because of an intrinsic instability of the enzyme. We identified a 5-LOX-specific destabilizing sequence that is involved in orienting the carboxyl terminus, which binds the catalytic iron. Here, we report the crystal structure at 2.4 angstrom resolution of human 5-LOX stabilized by replacement of this sequence.
Publication Source (Journal or Book title)
Science
First Page
217
Last Page
219
Recommended Citation
Gilbert, N., Bartlett, S., Waight, M., Neau, D., Boeglin, W., Brash, A., & Newcomer, M. (2011). The structure of human 5-lipoxygenase. Science, 331 (6014), 217-219. https://doi.org/10.1126/science.1197203
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