Document Type
Article
Publication Date
12-20-2018
Abstract
© 2018 Elsevier Ltd Small-molecule inhibitors of glycosylation can be applied in basic science studies, and clinical investigations as anti-inflammatory, anti-metastatic, and anti-viral therapies. This article demonstrates that thioglycosides represent a class of potent metabolic decoys that resist hydrolysis, and block E-selectin-dependent leukocyte adhesion in models of inflammation.
Publication Source (Journal or Book title)
Cell Chemical Biology
First Page
1519
Last Page
1532.e5
Recommended Citation
Wang, S., Gao, X., Solar, V., Yu, X., Antonopoulos, A., Friedman, A., Matich, E., Atilla-Gokcumen, G., Nasirikenari, M., Lau, J., Dell, A., Haslam, S., Laine, R., Matta, K., & Neelamegham, S. (2018). Thioglycosides Are Efficient Metabolic Decoys of Glycosylation that Reduce Selectin Dependent Leukocyte Adhesion. Cell Chemical Biology, 25 (12), 1519-1532.e5. https://doi.org/10.1016/j.chembiol.2018.09.012