"Alternating magnetic field mediated release of fluorophores from magne" by Jonathan S. Casey, Julien H. Arrizabalaga et al.

Faculty Publications

Title

Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating

Authors

Jonathan S. Casey, The Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, United States.
Julien H. Arrizabalaga, The Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, United States.
Mohammad Abu-Laban, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, United States.
Jeffrey C. Becca, The Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, United States.
Benjamin J. Rose, The Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, United States.
Kevin T. Strickland, The Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, United States.
Jacob B. Bursavich, The Department of Agricultural and Biological Engineering, Louisiana State University, Baton Rouge, LA 70803, United States.

Document Type

Article

Publication Date

7-1-2020

Abstract

This study explores the use of differential heating of magnetic nanoparticles with different sizes and compositions (MFeO (M = Fe, Co)) for heteroplexed temporal controlled release of conjugated fluorophores from the surface of nanoparticles. By exploiting these differences, we were able to control the amount of hysteretic heating occurring with the distinct sets of magnetic nanoparticles using the same applied alternating magnetic field radio frequency (AMF-RF). Using thermally labile retro-Diels-Alder linkers conjugated to the surface of nanoparticles, the fluorescent payload from the different nanoparticles disengaged when sufficient energy was locally generated during hysteretic heating. 1H, 13C NMR, ESI-MS, and SIMS characterized the thermally responsive fluorescent cycloadducts used in this study; the Diels Alder cycloadducts were modeled using density functional theory (DFT) computations. The localized point heating of the different nanoparticle compositions drove the retro-Diels-Alder reaction at different times resulting in higher release rates of fluorophores from the CoFeO compared to the FeO nanoparticles.

Publication Source (Journal or Book title)

Journal of colloid and interface science

First Page

348

Last Page

355

Recommended Citation

Casey, J. S., Arrizabalaga, J. H., Abu-Laban, M., Becca, J. C., Rose, B. J., Strickland, K. T., & Bursavich, J. B. (2020). Alternating magnetic field mediated release of fluorophores from magnetic nanoparticles by hysteretic heating. Journal of colloid and interface science, 571, 348-355. https://doi.org/10.1016/j.jcis.2020.03.056

Link to Full Text

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