"Lignin-Graft-Poly(lactic-co-glycolic) Acid Biopolymers for Polymeric N" by Carlos E. Astete, Judith U. De Mel et al.

Faculty Publications

Title

Lignin-Graft-Poly(lactic-co-glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis

Authors

Carlos E. Astete, Biological & Agricultural Engineering Department, Louisiana State University and LSU Ag Center, 149 E. B. Doran Bldg., Baton Rouge, Louisiana 70803, United States.
Judith U. De Mel, Department of Chemistry, Louisiana State University, Baton Rouge, 331 Chemistry and Materials Bldg, Louisiana 70803, United States.
Sudipta Gupta, Department of Chemistry, Louisiana State University, Baton Rouge, 331 Chemistry and Materials Bldg, Louisiana 70803, United States.
YeRim Noh, Department of Chemistry, Louisiana State University, Baton Rouge, 331 Chemistry and Materials Bldg, Louisiana 70803, United States.
Markus Bleuel, A235 NIST Center for Neutron Research National Institute of Standards and Technology, Gaithersburg, Maryland 20988-8562, United States.
Gerald J. Schneider, Department of Chemistry, Louisiana State University, Baton Rouge, 331 Chemistry and Materials Bldg, Louisiana 70803, United States.
Cristina M. Sabliov, Biological & Agricultural Engineering Department, Louisiana State University and LSU Ag Center, 149 E. B. Doran Bldg., Baton Rouge, Louisiana 70803, United States.

Document Type

Article

Publication Date

5-5-2020

Abstract

A lignin-graft-poly(lactic--glycolic) acid (PLGA) biopolymer was synthesized with two types of lignin (LGN), alkaline lignin (ALGN) and sodium lignosulfonate (SLGN), at different (A/S)LGN/PLGA ratios (1:2, 1:4, and 1:6 w/w). H NMR and Fourier-transform infrared spectroscopy (FT-IR) confirmed the conjugation of PLGA to LGN. The (A/S)LGN-graft-PLGA biopolymers were used to form nanodelivery systems suitable for entrapment and delivery of drugs for disease treatment. The LGN-graft-PLGA NPs were generally small (100-200 nm), increased in size with the amount of PLGA added, monodisperse, and negatively charged (-48 to -60 mV). Small-angle scattering data showed that particles feature a relatively smooth surface and a compact spherical structure with a distinct core and a shell. The core size and shell thickness varied with the LGN/PLGA ratio, and at a 1:6 ratio, the particles deviated from the core-shell structure to a complex internal structure. The newly developed (A/S)LGN-graft-PLGA NPs are proposed as a potential delivery system for applications in biopharmaceutical, food, and agricultural sectors.

Publication Source (Journal or Book title)

ACS omega

First Page

9892

Last Page

9902

Recommended Citation

Astete, C. E., De Mel, J. U., Gupta, S., Noh, Y., Bleuel, M., Schneider, G. J., & Sabliov, C. M. (2020). Lignin-Graft-Poly(lactic-co-glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis. ACS omega, 5 (17), 9892-9902. https://doi.org/10.1021/acsomega.0c00168

Link to Full Text

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