Delivery of alpha-tocopherol through soluble dietary fibre-based nanofibres for improving the life span of Caenorhabditis elegans

Authors

Juan Li, School of Nutrition and Food Sciences , Louisiana State University Agricultural Center , Baton Rouge , LA , USA.
Arranee Chotiko, Faculty of Science and Technology , Rajamangala University of Technology Thanyaburi , Pathum Thani , Thailand.
Alexander Chouljenko, School of Nutrition and Food Sciences , Louisiana State University Agricultural Center , Baton Rouge , LA , USA.
Chenfei Gao, School of Nutrition and Food Sciences , Louisiana State University Agricultural Center , Baton Rouge , LA , USA.
Jolene Zheng, Bioactive Screening Lab Pennington Biomedical Research Center, LSU System , Baton Rouge , LA , USA.
Subramaniam Sathivel, School of Nutrition and Food Sciences , Louisiana State University Agricultural Center , Baton Rouge , LA , USA.

Document Type

Article

Publication Date

3-1-2019

Abstract

The effect of alpha-tocopherol (α-TOC) delivered by soluble dietary fibre-based nanofibres (α-TOC-SDNF) on the life span of nematode Caenorhabditis elegans N2 (wild type) and TK22 (mev-1 mutants) with and without heat shock was investigated. Without heat shock, the wild-type and mev-1 mutants maintained in the 100 µg/mL of α-TOC-SDNF had longer life spans than their respective blank control groups. With heat shock, the wild-type N2 in the 200 µg/mL of α-TOC-SDNF had a survival rate of 5% at day 49, while no nematodes survived in the blank control group. An increased pharyngeal pumping rate was observed in the α-TOC-SDNF treated mev-1 mutants worms compared to the blank control group. Encapsulating α-TOC in SDNF yielded protective effects and the life span and pumping rate of C. elegans was increased with α-TOC delivered by SDNF.

Publication Source (Journal or Book title)

International journal of food sciences and nutrition

First Page

172

Last Page

181

Recommended Citation

Li, J., Chotiko, A., Chouljenko, A., Gao, C., Zheng, J., & Sathivel, S. (2019). Delivery of alpha-tocopherol through soluble dietary fibre-based nanofibres for improving the life span of Caenorhabditis elegans. International journal of food sciences and nutrition, 70 (2), 172-181. https://doi.org/10.1080/09637486.2018.1489785