"Canine hip dysplasia: A natural animal model for human developmental d" by Cecilia Pascual-Garrido, Farshid Guilak et al.

Faculty Publications

Title

Canine hip dysplasia: A natural animal model for human developmental dysplasia of the hip

Authors

Cecilia Pascual-Garrido, Department of Orthopaedic Surgery, School of Medicine, Musculoskeletal Research Center, Washington University, 660 S. Euclid, Campus Box 8233, Saint Louis, Missouri, 63110.
Farshid Guilak, Department of Orthopaedic Surgery, School of Medicine, Musculoskeletal Research Center, Washington University, 660 S. Euclid, Campus Box 8233, Saint Louis, Missouri, 63110.
M Farooq Rai, Department of Orthopaedic Surgery, School of Medicine, Musculoskeletal Research Center, Washington University, 660 S. Euclid, Campus Box 8233, Saint Louis, Missouri, 63110.
Michael D. Harris, Program in Physical Therapy, School of Medicine, Washington University, Saint Louis, Missouri.
Mandi J. Lopez, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana.
Rory J. Todhunter, College of Veterinary Medicine, Cornell University, Ithaca, New York.
John C. Clohisy, Department of Orthopaedic Surgery, School of Medicine, Musculoskeletal Research Center, Washington University, 660 S. Euclid, Campus Box 8233, Saint Louis, Missouri, 63110.

Document Type

Article

Publication Date

7-1-2018

Abstract

Developmental dysplasia of the hip (DDH) in humans is a common condition that is associated with hip pain, functional limitations, and secondary osteoarthritis (OA). Surgical treatment of DDH has improved in the last decade, allowing excellent outcomes at short- and mid-term follow-up. Still, the etiology, mechanobiology, and pathology underlying this disease are not well understood. A pre-clinical animal model of DDH could help advance the field with a deeper understanding of specific pathways that initiate hip joint degeneration secondary to abnormal biomechanics. An animal model would also facilitate different interventional treatments that could be tested in a rigorous and controlled environment. The dog model exhibits several important characteristics that make it valuable as a pre-clinical animal model for human DDH. Dogs are naturally prone to develop canine hip dysplasia (CHD), which is treated in a similar manner as in humans. Comparable to human DDH, CHD is considered a pre-OA disease; if left untreated it will progress to OA. However, progression to OA is significantly faster in dogs than humans, with progression to OA within 1-2 years of age, associated with their shorter life span compared to humans. Animal studies could potentially reveal the underlying biochemical pathway(s), which can inform refined treatment modalities and provide opportunities for new treatment and prevention targets. Herein, we review the similarities and differences between the two species and outline the argument supporting CHD as an appropriate pre-clinical model of human DDH. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:1807-1817, 2018.

Publication Source (Journal or Book title)

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

First Page

1807

Last Page

1817

Recommended Citation

Pascual-Garrido, C., Guilak, F., Rai, M. F., Harris, M. D., Lopez, M. J., Todhunter, R. J., & Clohisy, J. C. (2018). Canine hip dysplasia: A natural animal model for human developmental dysplasia of the hip. Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 36 (7), 1807-1817. https://doi.org/10.1002/jor.23828

Link to Full Text

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