Document Type
Article
Publication Date
1-1-2019
Abstract
© Zhang et al. Mitochondria change their shape through fusion and fission in order to adapt to their metabolic milieu. Mitofusin-2 (MFN2) is a key regulatory protein in this process, mediating mitochondrial fusion and interaction with endoplasmic reticulum. Targeted deletion of Mfn2 in oocytes resulted in mitochondrial dysfunction and female subfertility associated with impaired oocyte maturation and follicle development. Oocytes lacking MFN2 showed shortened telomeres and increased apoptosis, resulting in compromised oocyte quality and accelerated follicular depletion, consistent with a reproductive aging phenotype.
Publication Source (Journal or Book title)
Aging
First Page
3919
Last Page
3938
Recommended Citation
Zhang, M., Bener, M., Jiang, Z., Wang, T., Esencan, E., Scott, R., Horvath, T., & Seli, E. (2019). Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging, 11 (12), 3919-3938. https://doi.org/10.18632/aging.102024