Immunologic protection of rabbit corneal allografts with heterologous blocking antibody

Document Type

Article

Publication Date

1-1-1975

Abstract

We performed exchange penetrating keratoplasties in New Zealand White rabbits by using corneas soaked in heterologous "blocking" antibody (guinea pig antirabbit lymphocyte globulin) under various experimental situations and immunogenic stimuli. Results suggested that the antibody can protect the corneal graft from a weak rejection response possibly by blocking the afferent arc of the immunologic rejection reflex, but cannot protect a graft subject to a strong immunologic rejection episode. Based on these results, the use of a blocking antibody in human transplantation would be of potential benefit and offer little risk to a graft recipient. © 1975.

Publication Source (Journal or Book title)

American Journal of Ophthalmology

First Page

949

Last Page

954

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