In vitro demonstration of cytotoxic antibodies and their possible role in corneal graft rejections

Authors

P. S. Binder, University of Florida College of Medicine
J. W. Chandler, University of Florida College of Medicine
H. E. Kaufman, University of Florida College of Medicine

Document Type

Article

Publication Date

12-1-1976

Abstract

Rabbit corneas were exposed to heterologous guinea pig anti rabbit antibodies in the presence of complement and cytotoxic damage to the endothelium was demonstrated using para nitroblue tetrazolium. The possible role of such antibodies as 'blocking antibodies' and as cytotoxic antibodies in the corneal graft rejection process are discussed.

Publication Source (Journal or Book title)

Investigative Ophthalmology

First Page

481

Last Page

484

Recommended Citation

Binder, P., Chandler, J., & Kaufman, H. (1976). In vitro demonstration of cytotoxic antibodies and their possible role in corneal graft rejections. Investigative Ophthalmology, 15 (6), 481-484. Retrieved from https://repository.lsu.edu/animalsciences_pubs/2422