Analysis of viral DNA in isolates from patients with recurrent herpetic keratitis

Document Type

Article

Publication Date

1-1-1984

Abstract

Isolates were obtained from 10 patients with recurrent herpes simplex type 1 infection of the eye, lids, or mouth. The viral DNA of successive isolates from each patient was analyzed by restriction endonuclease fingerprinting. Evaluation of the DNA banding patterns of all isolates by means of two different enzymes, performed in a masked fashion, demonstrated that all of the isolates from any one patient had the same genetic makeup. These results indicate that recurrent herpes infections of the eye and face in humans are caused not by unrelated, serial infections but rather by reactivation of the same latent virus that remains in the ganglion over a period of years.

Publication Source (Journal or Book title)

Investigative Ophthalmology and Visual Science

First Page

951

Last Page

954

This document is currently not available here.

Share

COinS