Document Type
Article
Publication Date
1-1-1986
Abstract
A reduction in the incidence of rejection of mouse heterotopic corneal allografts was achieved by in vitro pretreatment of the graft with ultraviolet light. By day 21, 68% of untreated BALB/c corneas trans-planted into s.c. abdominal pouches of C57BL/6 recipi-ents demostrated rejection In contrast, corneas pre-treated with UV-A, -B, or -C at 150 mJ/cm2 showed an incidence of rejection at day 21 of 30%, 33% and 18%, respectively. Experiments indicate a significant reduction in rejection with doses of UV-B radiation above 75 mJ/cm. 2 The mechanism of this reduction is unknown, but may be due to a depletion or alteration of ocular surface Langerhans cells residing in the corneal epithelium. © 1986 by The Williams & Wilkins Co.
Publication Source (Journal or Book title)
Transplantation
First Page
403
Last Page
406
Recommended Citation
Ray-Keil, L., & Chandler, J. (1986). Reduction in the incidence of rejection of heterotopic murine corneal transplants by pretreatment with ultraviolet radiation. Transplantation, 42 (4), 403-406. https://doi.org/10.1097/00007890-198610000-00015