HLA-DR+/T6- Langerhans cells of the human cornea

Document Type

Article

Publication Date

1-1-1987

Abstract

We have investigated normal human corneas for the presence of T6-marker on Langerhans cells. With the exception of one pair of newborn corneas and two pairs of very young infant corneas, all HLA-DR-positive cells in central and peripheral corneal epithelium were T6-negative by double-labeled immunofluorescence. In contrast, epidermal sheets from normal human eyelid skin displayed positive staining for T6 on most of the HLA-DR-positive Langerhans cells. Since T6 antigen is considered to be a specific Langerhans cell differentiation marker, we interpret this finding to indicate a nonactivated or undifferentiated state of Langerhans cells in normal human corneas.

Publication Source (Journal or Book title)

Investigative Ophthalmology and Visual Science

First Page

1719

Last Page

1722

This document is currently not available here.

Share

COinS