Document Type
Article
Publication Date
1-1-2014
Abstract
© 2014 Future Science Ltd. Aim: To quantify in vivo the biodistribution of poly(lactic-co-glycolic) acid (PLGA) and PLGA/chitosan nanoparticles (PLGA/Chi NPs) and assess if the positive charge of chitosan significantly enhances nanoparticle absorption in the GI tract.Material & methods: PLGA and PLGA/Chi NPs covalently linked to tetramethylrhodamine-5-isothiocyanate (TRITC) were orally administered to F344 rats for 7 days, and the biodistribution of fluorescent NPs was analyzed in different organs.Results: The highest amount of particles (% total dose/g) was detected for both treatments in the spleen, followed by intestine and kidney, and then by liver, lung, heart and brain, with no significant difference between PLGA and PLGA/Chi NPs.Conclusion: Only a small percentage of orally delivered NPs was detected in the analyzed organs. The positive charge conferred by chitosan was not sufficient to improve the absorption of the PLGA/Chi NPs over that of PLGA NPs.
Publication Source (Journal or Book title)
Therapeutic Delivery
First Page
1191
Last Page
1201
Recommended Citation
Navarro, S., Darensbourg, C., Cross, L., Stout, R., Coulon, D., Astete, C., Morgan, T., & Sabliov, C. (2014). Biodistribution of PLGA and PLGA/chitosan nanoparticles after repeat-dose oral delivery in F344 rats for 7 days. Therapeutic Delivery, 5 (11), 1191-1201. https://doi.org/10.4155/tde.14.79