Evidence of a major gene effect for angiotensinogen among Nigerians

Document Type

Article

Publication Date

7-1-1999

Abstract

To dissect the genetic pathway of hypertension, we measured angiotensinogen in 685 members of 186 families recruited from a rural community in southwest Nigeria. Commingling and segregation analyses were carried out. A mixture of two and/or three distributions fits the data significantly better than a single distribution in commingling analysis, suggesting a major gene effect. Segregation analysis confirmed that a recessive major gene model for low values of angiotensinogen provides the best fit to the data and about 13% of the variance was due to the recessive gene segregation.

Publication Source (Journal or Book title)

Annals of Human Genetics

First Page

293

Last Page

300

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