Document Type
Article
Publication Date
1-1-2002
Abstract
A genome-wide scan using 387 short tandem repeat markers was conducted for obesity among 618 black individuals from 202 families residing in a suburb of Chicago. Evidence for linkage was evaluated with BMI and percent body fat (PBF) using a variance component analysis approach. Suggestive evidence for linkage was found for BMI on chromosome 5 (logarithm of odds [LOD] score = 1.9) and PBF on chromosome 6 (LOD score = 2.7). One additional region on chromosome 3 was linked to these phenotypes at a lower level of significance (LOD score = 1.8 and 0.95 for BMI and PBF, respectively); the linked marker on this chromosome lies in the same region implicated as harboring obesity genes in a previous study of a white population. The replication of linkage evidence using different ethnic groups reinforces the potential significance of this latter candidate region.
Publication Source (Journal or Book title)
Diabetes
First Page
541
Last Page
544
Recommended Citation
Zhu, X., Cooper, R., Luke, A., Chen, G., Wu, X., Kan, D., Chakravarti, A., & Weder, A. (2002). A genome-wide scan for obesity in African-Americans. Diabetes, 51 (2), 541-544. https://doi.org/10.2337/diabetes.51.2.541