Markers that discriminate between European and African ancestry show limited variation within Africa
Document Type
Article
Publication Date
12-1-2002
Abstract
Markers informative for ancestry are necessary for admixture mapping and improving case-control association analyses. In particular, African Americans are an admixed population for which genetic studies require accurately evaluating admixture. This will require markers that can be used in African Americans to determine if a given genomic region is European or African ancestry. This report shows that, despite studies indicating high intra-African sequence variation, markers with large inter-ethnic differences have only small variations in allele distribution among divergent African populations and should be valuable for evaluating admixture in complex disease genetic studies. © Springer-Verlag 2002.
Publication Source (Journal or Book title)
Human Genetics
First Page
566
Last Page
569
Recommended Citation
Collin-Schramm, H., Kittles, R., Operario, D., Weber, J., Criswell, L., Cooper, R., & Seldin, M. (2002). Markers that discriminate between European and African ancestry show limited variation within Africa. Human Genetics, 111 (6), 566-569. https://doi.org/10.1007/s00439-002-0818-z