A common genetic variant is associated with adult and childhood obesity
Document Type
Article
Publication Date
4-14-2006
Abstract
Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.
Publication Source (Journal or Book title)
Science
First Page
279
Last Page
283
Recommended Citation
Herbert, A., Gerry, N., McQueen, M., Heid, I., Pfeufer, A., Illig, T., Wichmann, H., Meitinger, T., Hunter, D., Hu, F., Colditz, G., Hinney, A., Hebebrand, J., Koberwitz, K., Zhu, X., Cooper, R., Ardlie, K., Lyon, H., Hirschhorn, J., Laird, N., Lenburg, M., Lange, C., & Christman, M. (2006). A common genetic variant is associated with adult and childhood obesity. Science, 312 (5771), 279-283. https://doi.org/10.1126/science.1124779