Document Type
Article
Publication Date
5-1-2007
Abstract
The neuropeptide Y (NPY) family of peptides and receptors regulate food intake. Inherited variation in this pathway could influence susceptibility to obesity and its complications, including type 2 diabetes. We genotyped a set of 71 single nucleotide polymorphisms (SNPs) that capture the most common variation in NPY, PPY, PYY, NPY1R, NPY2R, and NPY5R in 2,800 individuals of recent European ancestry drawn from the near extremes of BMI distribution. Five SNPs located upstream of NPY2R were nominally associated with BMI in men (P values = 0.001-0.009, odds ratios [ORs] 1.27-1.34). No association with BMI was observed in women, and no consistent associations were observed for other genes in this pathway. We attempted to replicate the association with BMI in 2,500 men and tested these SNPs for association with type 2 diabetes in 8,000 samples. We observed association with BMI in men in only one replication sample and saw no association in the combined replication samples (P = 0.154, OR = 1.09). Finally, a 9% haplotype was associated with type 2 diabetes in men (P = 1.73 × 10-4, OR = 1.36) and not in women. Variation in this pathway likely does not have a major influence on BMI, although small effects cannot be ruled out; NPY2R should be considered a candidate gene for type 2 diabetes in men. © 2007 by the American Diabetes Association.
Publication Source (Journal or Book title)
Diabetes
First Page
1460
Last Page
1467
Recommended Citation
Campbell, C., Lyon, H., Nemesh, J., Drake, J., Tuomi, T., Gaudet, D., Zhu, X., Cooper, R., Ardlie, K., Groop, L., & Hirschhorn, J. (2007). Association studies of BMI and type 2 diabetes in the neuropeptide y pathway: A possible role for NPY2R as a candidate gene for type 2 diabetes in men. Diabetes, 56 (5), 1460-1467. https://doi.org/10.2337/db06-1051