Drug-induced modifications of the immune response 13. Potassium 2,5-dihydro-3-ethoxycarbonyl-2-phenylimino-4-furanyloxides as novel anti-allergic agents

Document Type

Article

Publication Date

1-1-1989

Abstract

The synthesis and anti-allergic activity of novel potassium 2,5-dihydro-3-ethoxycarbonyl-2-phenylimino-4-furanyloxides are described. The salts were found to exert moderate to potent activity in vivo in the mediator-induced dermal vascular permeability and active anaphylaxis assays in rats. The 2-(4-acetylphenyl)imino derivative 6c was the most active compound. Following its intraperitoneal administration to rats at a dose of 100 mg/kg, derivative 6c inhibited both the wheal reaction caused by serotonin, histamine and bradykinin (by 79, 88 and 86%, respectively) and active anaphylaxis by 56%. © 1989.

Publication Source (Journal or Book title)

European Journal of Medicinal Chemistry

First Page

61

Last Page

64

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