Novel potential myocardial perfusion imaging agent [^99mTcN (PNP5) (NOEt)]⁺

Authors

Jin Feng Chu, Beijing University of Chemical Technology
Bin Li, Beijing Normal University
De Jing Kong, Beijing Normal University
Xue Bin Wang, Beijing Normal University
Jun Bo Zhang, Beijing Normal University
Jin Cheng Wang, Beijing Anzhen Hospital, Capital Medical University
Hong Zhi Mi, Beijing Anzhen Hospital, Capital Medical University
Jian Dong Zhao, Beijing Anzhen Hospital, Capital Medical University

Document Type

Article

Publication Date

6-1-2005

Abstract

[99mTcN(PNP5)(NOEt)]+ was prepared through ligand exchange reaction and its radiochemical purity was over 90% measured by TLC and HPLC. The results of charge character and stability studies indicate that [99mTcN(PNP5)(NOEt)]+ is a cation with a good stability. Studies on the biodistribution in mice and SPECT imaging in dog show that [99mTcN(PNP5)(NOEt)]+ possessed a high myocardial uptake and good retention, and high target to non-target ratios, suggesting that it may be a potential myocardial perfusion imaging agent.

Publication Source (Journal or Book title)

Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

First Page

1014

Last Page

1017

Recommended Citation

Chu, J., Li, B., Kong, D., Wang, X., Zhang, J., Wang, J., Mi, H., & Zhao, J. (2005). Novel potential myocardial perfusion imaging agent [^99mTcN (PNP5) (NOEt)]⁺. Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities, 26 (6), 1014-1017. Retrieved from https://repository.lsu.edu/ag_exst_pubs/952