Nano-manipulation of single DNA molecules based on atomic force microscopy
Document Type
Conference Proceeding
Publication Date
12-1-2005
Abstract
Nano-manipulation of single atoms and molecules is a critical technique in nanoscience and nanotechnology. This paper will focus on the recent development of the manipulation of single DNA molecules based on atomic force microscopy (AFM) in our laboratory. Precise manipulation has been realized including varied manipulating modes such as "cutting", "pushing", "folding", "kneading", "picking up", "dipping", etc. The cutting accuracy is dominated by the size of the AFM tip, which is usually 10nm or less. Single DNA fragments can be cut and picked up and then amplified by single molecule PCR. Thus positioning isolation and sequencing can be performed. © 2005 IEEE.
Publication Source (Journal or Book title)
Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
First Page
7478
Last Page
7481
Recommended Citation
Lü, J., Li, H., An, H., Wang, G., Wang, Y., Li, M., Zhang, Y., Li, B., & Hu, J. (2005). Nano-manipulation of single DNA molecules based on atomic force microscopy. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 7 VOLS, 7478-7481. Retrieved from https://repository.lsu.edu/ag_exst_pubs/912