Proline catalyzed asymmetric aldol reaction between methyl ketones and α-ketoesters

Document Type

Article

Publication Date

9-1-2006

Abstract

Direct asymmetric aldol additions of acetone/and butanone to α-ketoesters were achieved using L-proline as a chiral catalyst. Various optically active α-hydroxyesters were obtained in the yields of 43%-93% with enantioselectivities up to 81% e.e. The steric effect seems to be an important factor which influences the activity and the selectivity of the reaction. Acetone showed higher reactivity than butanone while the latter provided better enantioselectivity in some cases. © 2006 SIOC, CAS, & Wiley-VCH Verlag GmbH & Co. KGaA.

Publication Source (Journal or Book title)

Chinese Journal of Chemistry

First Page

1196

Last Page

1199

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