Synthesis and evaluation of 8-[¹³¹I]iodo-substituted imidazopyridine derivative as single photon emission computed tomography tracer for peripheral benzodiazepine receptors

Authors

Bin Li, Shanghai Jiao Tong University
Jian Feng Li, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
Xiao Guang Sun, Shanghai Jiao Tong University
Gang Huang, Shanghai Jiao Tong University

Document Type

Article

Publication Date

11-1-2006

Abstract

A novel N-methyl, N-phenyl-[6-chloro-2-(4-chlorophenyl)-8-iodoimidazo[1, 2-a]-pyridine-3-yl]acetamide (compound V) was synthesized, radiolabelled with 131I and evaluated in vitro. In vitro cell uptake studies showed that MDA-MB-231 cells yield four-fold higher specific uptake of [ 131I]-compound VI than MCF-7 cells, corresponding to the increased expression of PBR in MDA-MB-231 cells. Blocking studies significantly reduced the MDA-MB-231 cells uptake of [131I]-compound VI. It indicated that [131I]-compound VI might be a potential SPECT radioligand for imaging of PBR.

Publication Source (Journal or Book title)

Chinese Chemical Letters

First Page

1435

Last Page

1438

Recommended Citation

Li, B., Li, J., Sun, X., & Huang, G. (2006). Synthesis and evaluation of 8-[¹³¹I]iodo-substituted imidazopyridine derivative as single photon emission computed tomography tracer for peripheral benzodiazepine receptors. Chinese Chemical Letters, 17 (11), 1435-1438. Retrieved from https://repository.lsu.edu/ag_exst_pubs/853