Experimental study of [99mTc(PNP5) (DBODC)]+ as a new myocardial perfusion imaging agent

Document Type

Article

Publication Date

12-1-2008

Abstract

Objectives: This study was aimed to compare the properties of [ 99mTc(PNP5)(DBODC)]+ with 99mTc-MIBI in normal swine and in canine models of myocardial ischemia. Methods: Seven anesthetized swine were injected intravenously with [99mTc(PNP5)(DBODC)] +. Serial planar images were acquired meanwhile. Twelve adult dogs were studied. A critical stenosis of left anterior descending artery was produced. [99mTc(PNP5)(DBODC)]+ or 99mTc-MIBI (randomly) was injected intravenously at the end of 3 min of adenosine infusion. The occluder was released after adenosine infusion. Myocardial SPECT imaging was obtained at 30, 60, 90 and 180 min, respectively, after tracer injection. Rest myocardial SPECT imaging was acquired on the next day. Results: Blood disappearance of [99mTc(PNP5)(DBODC)]+ was biexponential with an initial half-time of 2.97 ± 0.48 min and a late half-time of 52.49 ± 19.49 min. Myocardial [99mTc(PNP5)(DBODC)]+ uptake was similar to 99mTc-MIBI. Heart-to-liver ratio of [ 99mTc(PNP5)(DBODC)]+ was significantly higher than that of 99mTc-MIBI (0.99 ± 0.03 vs. 0.46 ± 0.10, p < 0.05) 30 min after injection. In canine models of myocardial ischemia, image quality of [99mTc(PNP5)(DBODC)]+ was better than 99mTc-MIBI. Segments with perfusion defects by [ 99mTc(PNP5)(DBODC)]+ was 3.60 ± 1.52 and 4.25 ± 0.96 by 99mTc-MIBI (p = n.s.). Conclusions: [ 99mTc(PNP5)(DBODC)]+ seems to be a promising new myocardial perfusion imaging agent. Copyright © 2008 S. Karger AG.

Publication Source (Journal or Book title)

Cardiology

First Page

89

Last Page

97

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