Clinical observation of three dimensional-conformal radiation therapy combined with chemotherapy for recurrent rectal cancer

Document Type

Article

Publication Date

9-28-2010

Abstract

OBJECTIVE, To study the outcome of recurrent rectal cancer treated by three dimensional-conformal radiation therapy (3D-CRT) combined with chemotherapy. METHODS, Fifty-seven patients with recurrent rectal cancer received 3D-CRT combined with chemotherapy. The prescription dose was 66 -70 Gy. All the patients were treated with oxaliplatin ( 100 mg/m2, d1 ) , combined with leucovorin (100 mg/m2, d1 -d5) and fluorouracil (500 mg/m2 , d1 -d5 ). RESULTS: The overall response rate was 92. 4%. The overall 1-, 2-, 3-year survival rates were 73.58% (39/53), 52. 83% (28/53) and 35. 85% (19/53) respectively. Eleven cases distantly metastasized and the distant metastasis rate was 20. 75%. The side effects were gastrointestinal reaction, bone marrow depression, radiation rectitis, and radiation urocystitis, and their degree mainly varied from Grade 1 to Grade 2. CONCLUSIONS: Three-dimensional cordormal radiotherapy with chemotherapy is able to prolong the survival of patients with recurrent rectal carcinoma. In addition, the side effects are minor and it can improve the quality of life of the patients.

Publication Source (Journal or Book title)

Chinese Journal of Cancer Prevention and Treatment

First Page

1473

Last Page

1475

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