Anti-HBV active flavone glucosides from Euphorbia humifusa Willd.
Document Type
Article
Publication Date
10-1-2010
Abstract
Thirteen flavone glucosides from the herb of Euphorbia humifusa were isolated and elucidated. Among them, five compounds including apigenin-7-O-β-d-glucopyranoside (2), apigenin-7-O-(6′′-O- galloyl)-β-d-glucopyranoside (3), luteolin-7-O-β-d-glucopyranoside (7), luteolin-7-O-(6′′-O-trans-feruloyl)-β-d-glucopyranoside (8) and luteolin-7-O-(6′′-O-coumaroyl)-β-d-glucopyranoside (9) showed anti-HBV activity in vitro. The structure-activity relationship showed that the parent structure was closely relevant to the anti-HBV activity of these compounds (agigenin > luteolin > quercetin). It was found that the number of glucoside in the structure may significantly influence their activities (flavone monoglucoside > flavone diglucoside) and cytotoxicity (flavone > flavone monoglucoside > flavone diglucoside). In addition, the substitution of acyl group on glucoside may be important to keep the anti-HBV activities of these compounds (galloyl > feruloyl > coumaroyl). © 2010 Elsevier B.V. All rights reserved.
Publication Source (Journal or Book title)
Fitoterapia
First Page
799
Last Page
802
Recommended Citation
Tian, Y., Sun, L., Liu, X., Li, B., Wang, Q., & Dong, J. (2010). Anti-HBV active flavone glucosides from Euphorbia humifusa Willd.. Fitoterapia, 81 (7), 799-802. https://doi.org/10.1016/j.fitote.2010.04.012