Steroidal glycosides from the rhizomes of anemarrhena asphodeloides and their antiplatelet aggregation activity
Document Type
Article
Publication Date
2-3-2012
Abstract
Five new steroidal glycosides, timosaponin J (1), timosaponin K (2), (25S)-karatavioside C (5), timosaponin L (6), and (25S)-officinalisnin-I (8), together with eight known steroidal saponins, timosaponin E1 (3), purpureagitosid (4), timosaponin BII (7), timosaponin B III (9), anemarrhenasaponin I (10), anemarrhenasaponin III (11), anemarrhenasaponin A2 (12), and timosaponin A III (13), were isolated from the rhizomes of Anemarrhena asphodeloides. Their structures were elucidated on the basis of spectroscopic and chemical evidence. The aglycones of compounds 1 and 2 are new aglycones. Compounds 1-13 were evaluated for their platelet aggregation activities, and compound 13 exhibited the strongest inhibitory effect on adenosine diphosphate (ADP)-induced platelet aggregation.
Publication Source (Journal or Book title)
Planta Medica
First Page
611
Last Page
616
Recommended Citation
Kang, L., Zhang, J., Cong, Y., Li, B., Xiong, C., Zhao, Y., Tan, D., Yu, H., Yu, Z., Cong, Y., Liu, C., & Ma, B. (2012). Steroidal glycosides from the rhizomes of anemarrhena asphodeloides and their antiplatelet aggregation activity. Planta Medica, 78 (6), 611-616. https://doi.org/10.1055/s-0031-1298223
