Selective uptake of boronophenylalanine by glioma stem/progenitor cells

Authors

Ting Sun, The First Affiliated Hospital of Soochow University
Youxin Zhou, The First Affiliated Hospital of Soochow University
Xueshun Xie, The First Affiliated Hospital of Soochow University
Guilin Chen, The First Affiliated Hospital of Soochow University
Bin Li, The First Affiliated Hospital of Soochow University
Yongxin Wei, The First Affiliated Hospital of Soochow University
Jinming Chen, The First Affiliated Hospital of Soochow University
Qiang Huang, Second Affiliated Hospital of Suzhou University
Ziwei Du, The First Affiliated Hospital of Soochow University

Document Type

Article

Publication Date

8-1-2012

Abstract

The success of boron neutron capture therapy (BNCT) depends on the amount of boron in cells and the tumor/blood and tumor/(normal tissue) boron concentration ratios. For the first time, measurements of boron uptake in both stem/progenitor and differentiated glioma cells were performed along with measurements of boron biodistribution in suitable animal models. In glioma stem/progenitor cells, the selective accumulation of boronophenylalanine (BPA) was lower, and retention of boron after BPA removal was longer than in differentiated glioma cells in vitro. However, boron biodistribution was not statistically significantly different in mice with xenografts. © 2012 Elsevier Ltd.

Publication Source (Journal or Book title)

Applied Radiation and Isotopes

First Page

1512

Last Page

1518

Recommended Citation

Sun, T., Zhou, Y., Xie, X., Chen, G., Li, B., Wei, Y., Chen, J., Huang, Q., & Du, Z. (2012). Selective uptake of boronophenylalanine by glioma stem/progenitor cells. Applied Radiation and Isotopes, 70 (8), 1512-1518. https://doi.org/10.1016/j.apradiso.2012.04.005