Preparation and application of self-assembly of amphiphilic cyclotriphosphazene

Document Type

Article

Publication Date

8-10-2014

Abstract

A novel amphiphilic cyclotriphosphazene derivative was synthesized and its properties including chemical composition, crystalline state, thermostability and micromorphology were systematically characterized by FTIR, DSC and SEM. Meanwhile, the cytotoxicity of the compound was also tested. The special micro-structure with abundant ducts based on the long hydrophilic chain PEG was formed by the cyclotriphosphazene derivative via a self-assembled process, these ducts could be utilized as vehicles for loading curcumin and magnetic Fe3O4 nanoparticles. Furthermore, the micromorphology, crystalline state, thermostability and magnetite properties of the fabricated drug delivery system were thoroughly investigated and the drug-loaded mechanism was revealed.

Publication Source (Journal or Book title)

Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities

First Page

1675

Last Page

1680

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