Palladium-Catalyzed Double C-H Arylation Reaction: Tandem Synthesis of Benzo[ a ]imidazo[5,1,2- cd ]indolizines from Imidazo[1,2- a ]pyridines and o -Dihaloarenes
Document Type
Article
Publication Date
8-17-2015
Abstract
A palladium-catalyzed direct arylation of 2-arylimidazo[1,2-a]pyridines with o-dihaloarenes via double C-H activation is described. The process comprises intermolecular C3-arylation of 2-arylimidazo[1,2-a]pyridines followed by an intramolecular C5-arylation in a highly regioselective fashion, affording benzo[a]imidazo[5,1,2-cd]indolizine derivatives in moderate to good yields.
Publication Source (Journal or Book title)
Synthesis (Germany)
First Page
2457
Last Page
2466
Recommended Citation
Wang, H., Chen, C., Huang, Z., Yao, L., Li, B., & Peng, J. (2015). Palladium-Catalyzed Double C-H Arylation Reaction: Tandem Synthesis of Benzo[ a ]imidazo[5,1,2- cd ]indolizines from Imidazo[1,2- a ]pyridines and o -Dihaloarenes. Synthesis (Germany), 47 (16), 2457-2466. https://doi.org/10.1055/s-0034-1380865
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