Study of mechanism of reduction of 2-bromo-1-(p-X-phenyl) ethylidenemalononitrile by 1-benzyl-1,4-dihydronicotinamide and 10-methyl-9, 10-dihydroacridine

Authors

You Cheng Liu, State Key Laboratory of Applied Organic Chemistry
Bin Li, State Key Laboratory of Applied Organic Chemistry
Qing Xiang Guo, State Key Laboratory of Applied Organic Chemistry

Document Type

Article

Publication Date

8-28-1995

Abstract

The reduction of 2-bromo-1-(p-X-phenyl) ethylidenemalononitrile (X -BPM: X = H, F, Cl, Br, CN) by NADH models BNAH and AcrH2 has been investigated. Based on product analysis, kinetic isotope effect, and free energy relationship, a direct hydride transfer and an electron transfer-hydrogen abstraction mechanism is proposed, respectively. © 1995 Elsevier Science Ltd.

Publication Source (Journal or Book title)

Tetrahedron

First Page

9671

Last Page

9680

Recommended Citation

Liu, Y., Li, B., & Guo, Q. (1995). Study of mechanism of reduction of 2-bromo-1-(p-X-phenyl) ethylidenemalononitrile by 1-benzyl-1,4-dihydronicotinamide and 10-methyl-9, 10-dihydroacridine. Tetrahedron, 51 (35), 9671-9680. https://doi.org/10.1016/0040-4020(95)00559-Q