Syhthesis and Superoxide Dismutase Activity Studies of β-Cyclodextrin Derivatives Containing 1,2-Benzisoselenazol-3(2H)-one

Document Type

Article

Publication Date

8-10-2000

Abstract

Two novel β-cyclodextrin derivatives containing 1, 2-benzisoselenazol-3 (2H)-one have been synthesized by a convenient method in 60% and 55% yields, respectively, and characterized by elemental analysis, IR and 1H NMR. The superoxide dismutase (SOD) activity of these modified β-cyclodextrins has been determined by the method of autooxidation of pyrogallol at 298. 15 K in buffer solution (pH = 8. 20). The results obtained indicate that these cyclodextrin derivatives possesses relatively high SOD activity up to 179∼330 U/mg.

Publication Source (Journal or Book title)

Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities

First Page

1236

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