Synthesis of organoselenium-modified β-cyclodextrins possessing a 1,2-benzisoselenazol-3(2H)-one moiety and their enzyme-mimic study
Document Type
Article
Publication Date
2-23-2002
Abstract
Six novel H2O-soluble β-cyclodextrin derivatives containing a 1,2-benzisoselenazol-3(2H)-one moiety were synthesized by a convenient method in 25-60% yield and characterized by MS, elemental analysis, IR, 1H-NMR, and UV/VIS spectroscopy. The conformations of these β-cyclodextrin derivatives 1-6 were analyzed by circular dichroism and fluorescence-lifetime experiments. The superoxide dismutase (SOD) activities of 1-6 were determined by auto-oxidation of pyrogallol at 25.0° in buffer solution (pH 8.2), giving relatively high SOD activities of up to 121-330 U/mg. Also, the glutathione peroxidase (GPX) activities of hosts 1-6, determined by the method of Wilson at 37° in buffer solution (pH 7.0), show good GPX activities in the range of 0.34-0.86 U/μmol. The mimicking results of the bifunctional artificial enzyme models 1-6 were globally compared with regard to their structural and conformational difference.
Publication Source (Journal or Book title)
Helvetica Chimica Acta
First Page
9
Last Page
18
Recommended Citation
Liu, Y., Li, B., Li, L., & Zhang, H. (2002). Synthesis of organoselenium-modified β-cyclodextrins possessing a 1,2-benzisoselenazol-3(2H)-one moiety and their enzyme-mimic study. Helvetica Chimica Acta, 85 (1), 9-18. https://doi.org/10.1002/1522-2675(200201)85:1<9::AID-HLCA9>3.0.CO;2-H