Tuning T helper cell differentiation by ITK
CD4+ effector T cells effectuate T cell immune responses, producing cytokines to orchestrate the nature and type of immune responses. The non-receptor tyrosine kinase IL-2 inducible T cell kinase (ITK), a mediator of T cell Receptor signaling, plays a critical role in tuning the development of these effector cells. In this review we discussed the role that signals downstream of ITK, including the Ras/MAPK pathway, play in differentially controlling the differentiation of TH17, Foxp3+ T regulatory (Treg) cells, and Type 1 regulatory T (Tr1) cells, supporting a model of ITK signals controlling a decision point in the effector T cell differentiation process.
Publication Source (Journal or Book title)
Biochemical Society transactions
Elmore, J. P., McGee, M. C., Nidetz, N. F., Anannya, O., Huang, W., & August, A. (2020). Tuning T helper cell differentiation by ITK. Biochemical Society transactions, 48 (1), 179-185. https://doi.org/10.1042/BST20190486