The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions

Authors

Steve N. Georas, University of Rochester Medical Center
Rosalind J. Wright, Icahn School of Medicine at Mount Sinai
Anastasia Ivanova, UNC Gillings School of Global Public Health
Elliot Israel, Harvard Medical School
Lisa M. LaVange, UNC Gillings School of Global Public Health
Praveen Akuthota, University of California, San Diego
Tara F. Carr, The University of Arizona Health Sciences
Loren C. Denlinger, University of Wisconsin School of Medicine and Public Health
Merritt L. Fajt, University of Pittsburgh Medical Center
Rajesh Kumar, Children's Memorial Hospital
Wanda K. O'Neal, UNC School of Medicine
Wanda Phipatanakul, Boston Children's Hospital
Stanley J. Szefler, The Children's Hospital, Aurora
Mark A. Aronica, Cleveland Clinic Foundation
Leonard B. Bacharier, Vanderbilt University School of Medicine
Allison J. Burbank, UNC School of Medicine
Mario Castro, University of Kansas School of Medicine
Laura Crotty Alexander, University of California, San Diego
Julie Bamdad, National Heart, Lung, and Blood Institute (NHLBI)
Juan Carlos Cardet, University of South Florida, Tampa
Suzy A.A. Comhair, Cleveland Clinic Foundation
Ronina A. Covar, National Jewish Health
Emily A. DiMango, Columbia University Irving Medical Center
Kim Erwin, University of Illinois at Chicago
Serpil C. Erzurum, Cleveland Clinic Foundation
John V. Fahy, UCSF School of Medicine
Jonathan M. Gaffin, Boston Children's Hospital
Benjamin Gaston, Indiana University-Purdue University Indianapolis
Lynn B. Gerald, The University of Arizona Health Sciences
Eric A. Hoffman, University of Iowa Carver College of Medicine
Fernando Holguin, University of Colorado School of Medicine
Daniel J. Jackson, University of Wisconsin School of Medicine and Public Health
John James, UNC Gillings School of Global Public Health
Nizar N. Jarjour, University of Wisconsin School of Medicine and Public Health

Document Type

Article

Publication Date

2-1-2022

Abstract

Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate goal of modifying the natural history of disease. Here, we describe the Precision Interventions for Severe and/or Exacerbation-Prone Asthma (PrecISE) Network, a groundbreaking collaborative effort of asthma researchers and biostatisticians from around the United States. The PrecISE Network was designed to conduct phase II/proof-of-concept clinical trials of precision interventions in the population with severe asthma, and is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health. Using an innovative adaptive platform trial design, the PrecISE Network will evaluate up to 6 interventions simultaneously in biomarker-defined subgroups of subjects. We review the development and organizational structure of the PrecISE Network, and choice of interventions being studied. We hope that the PrecISE Network will enhance our understanding of asthma subtypes and accelerate the development of therapeutics for severe asthma.

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