Simulation and Design of Micro-mixers for Microfluidic Devices
Document Type
Conference Proceeding
Publication Date
5-10-2004
Abstract
Passive (diffusional) mixing has been used in designing high-aspect-ratio micro-mixers for the purpose of performing Liagase Detection Reaction (LDR). The types of mixers considered are simple, cheap, and durable and can perform over a broad range of volumetric flow rates at reasonably modest pressure drops. The fluids to be mixed have a very low typical diffusion coefficient of=1.2×10-10m2/s and diffusional mixing is only effective in high-aspect-ratio micro-channels. A very modestly high aspect ratio of 6 has been considered initially because it is easily releasable using the LIGA technique. Numerical simulations of a few basic diffusional mixer configurations are going to be presented in this paper. Two variants of a Y-rype mixer with contraction and several variants of a mixer employing jets in cross-flow have been simulated. The various mixers have been evaluated in terms of volumetric mixing efficiencies and maximum pressure drops. One of the mixers with jets-in-cross-flow was found to perform best.
Publication Source (Journal or Book title)
Proceedings of SPIE - The International Society for Optical Engineering
First Page
183
Last Page
193
Recommended Citation
Maha, A., Barrett, D., Nikitopoulos, D., Soper, S., & Murphy, M. (2004). Simulation and Design of Micro-mixers for Microfluidic Devices. Proceedings of SPIE - The International Society for Optical Engineering, 5345, 183-193. https://doi.org/10.1117/12.530788